Medicine: Swansea University Research Excellence Scholarship: Linking Genomic Data with Routinely-collected Health Data for Epilepsy Genotype-phenotype Research
- Full cost of UK/EU tuition fees, plus a stipend
- January 22, 2018
Swansea University Research Excellence Scholarships (SURES)
Swansea University is proud to offer 15 fully-funded PhD scholarships for students commencing study in October 2018 or January 2019.
The scholarships will be awarded on the basis of student excellence across a portfolio of 34 potential projects.
Project title: Linking Genomic Data with Routinely-collected Health Data for Epilepsy Genotype-phenotype Research
Start date: October 2018
Epilepsy is a common neurological disease with significant health and social co-morbidity. Although advances have been made in understanding its aetiology, prognosis and treatment, considerable uncertainties remain. This project will take the novel approach of using routinely-collected data linked with detailed genetic-sequencing data to address these uncertainties.
A wealth of routinely-collected data is available in the Secure Anonymised Information Linkage (SAIL) Databank. SAIL provides researchers with secure access to a large number of linked, anonymised datasets. The Swansea Neurology Group has over 720 DNA samples from people with epilepsy from a large Swansea-led infrastructure research project (the ‘Swansea Neurology Biobank’) with ‘exome sequencing’ coverage and permission to upload into SAIL.
This project will develop a platform to upload and anonymously link large genetic sequencing datasets (patient exomes) with routinely-collected data in SAIL and perform retrospective cohort studies. These studies would compare groups of epilepsy patients who show different levels of disease severity, treatment response, social deprivation and co-morbidity. The project will also compare clinical outcomes in those groups who show a gene-loading bias in terms of burden of predicted deleterious gene-variants (see Lancet Neurology 2017: 16(2),135–143). There is then scope to develop and apply techniques such as Mendelian randomisation, meta-dimensional analysis and ‘wet-lab’ genetic validation / gene-expression analysis.
The prospective student will join the large, inclusive, impact-winning Swansea Neurology Research group with a 100% PhD success-rate over 16 years (n=21) and be part of the Neurology SAIL team. They will also have access to our Postgraduate Research Student Training programmes.
Supervisors / Academic Contacts: Professor Mark Rees / Dr Owen Pickrell / Dr Seo-Kyung Chung
Candidates should have (or expect to obtain) a first class honours degree (or equivalent) and/or a master's degree with distinction in a related discipline (biomedical sciences, data-linkage, computer studies, mathematics or health epidemiology).
Experience with, or the ability to learn, analysis of large datasets, programming languages and bio-statistical techniques is required.
Due to funding restrictions, this scholarship is open to UK/EU candidates only.
The TOEFL® test is a popular option for students to meet the English-language requirements for scholarships.
The scholarship covers the full cost of UK/EU tuition fees and an annual stipend of £14,553 for 3 years.
There will also be £1,000 per annum available for research expenses such as travel, accommodation, field trips and conference attendance.
Please visit our website for more information.
Sign Up for Scholarship Updates
Get an email every week that 10.000's of students use to get the latest scholarships.