Medicine (Bacterial genomics): KESS II Funded MSc by Research Studentship at Swansea University: Draft genome assembly, bioprospecting and functional analysis of probiotic bacteria
- Full cost of UK/EU tuition fees, plus a stipend
- 31 August 2017
Swansea University is a UK top 30 institution for research excellence (Research Excellence Framework 2014), and has been named Welsh University of the Year 2017 by The Times and Sunday Times Good University Guide.
*This scholarships is part funded by the Welsh Government’s European Social Fund (ESF) convergence programme for West Wales and the Valleys.*
Cultech Limited are a South Wales based SME who specialize in the manufacturer of nutritional supplements and have earned global recognition as a pioneer in probiotic manufacture and research due to a long standing ethos of supporting their products with robust peer-reviewed scientific evidence. Probiotics are defined by the World Health Organization as “live micro-organisms which, when administered in adequate amounts, confer a health beneﬁt on the host” and there is now a growing body of evidence demonstrating that different probiotic species can illicit unique beneficial effects across a diverse range of disease states including inflammatory diseases, heart disease, neurodegenerative diseases and cancer. Over the last 10 years there has been a staggering increase in the number of studies characterizing the genomes of culturable bacteria in the human gut and Cultech Ltd has recognized the potential benefits of this genomic sequencing and they believe that it should be feasible to construct specific probiotic consortia targeting specific disease states on the basis of the genetic profiles. The project will use previously isolated probiotic bacteria and will deliver fully sequenced and annotated genome sequences. Identity and characterisation of strains will be undertaken using a thorough phylogenomic analysis. The data generated will be mined to gain an understanding of the potential/expected functionality and the performance of the bacteria. Moreover, a comparison of data generated by robust functional assays will be compared with the annotated genomes in order to assess the usefulness of genome mining as a predictor of bacterial function.
Candidates should have a 2.1 or above in their undergraduate degree and have a working knowledge of genome sequencing and annotation and phylogenetic reconstruction. They should also be eligible for UK/EU Fees.
The studentship covers the full cost of UK/EU tuition fees, plus a stipend. The bursary will be limited to a maximum of £11,472 p.a. dependent upon the applicant’s financial circumstances.
There will also be additional funds available for research expenses.
Please visit our website for more information.
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