Medical and Health Care Studies: Fully Funded KESS II MSc by Research Scholarship at Swansea University: Monitoring inflammatory response to pre-infectious pathogens

  • Full cost of UK/EU tuition fees, plus a stipend
  • Deadline: July 13, 2018
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*This scholarships is part funded by the Welsh Government’s European Social Fund (ESF) convergence programme for West Wales and the Valleys.*

Where potential changes to the microbiota are not characterised or specific diagnostic tests are not available, traditional culture-based diagnosis can be very difficult. Combined with their small size and limited blood volumes, the extent of diagnostic, prognostic, and research assays that can be performed on the small sample size is extremely limited. Innovative techniques including high-throughput analysis working at nanoscale level are enabling investigators to detect nucleic acids, metabolites and proteins from a minuscule volume of saliva, blood and body fluids. Furthermore patients in critical condition require serial monitoring for infection risk. The present proposal is targeting this gap. Gut microbiota/immunity has an essential role in human health contributing with homeostasis, stimulating development of immune system, protecting against pathogens, and involving in processing nutrients. Interfering on the gut microbiota has been linked to increasing number of diseases, including bowel disease, NEC, diabetes, obesity, cancer, allergy and asthma.

The present study will investigate biomarkers in the fluid samples from various body sites of participants (healthy and infected patients, n=20), with or without Candida infection. Biomarkers will be studied using nanosensors. Research participants’ ethical approval already in place.

Immune responses for Candida in salivary samples will be detected by biosensor method and compared by ELISA technique. In addition, in vitro immune response during interaction of Candida and immune cells (mononuclear and polymorphonuclear cells) will be investigated (Melo et al. 2017). Recently the supervising group has been collaborating in the development of specific biomarker targeted graphene biosensors and that have already been taken through proof of concept.   This study is a continuation to  support the translation of the proof of concept platform, and applying this detection platform in a clinical setting where there is a requirement to work with a very small sample volumes (

Eligibility

Candidates should have a 2.1 or above in their undergraduate degree or and MSc in biomedical sciences, nanomedicine or a related subject. They should also be eligible for UK/EU Fees.

We would normally expect the academic and English Language requirements to be met by point of application. For details on the University’s English Language entry requirements, please visit – http://www.swansea.ac.uk/admissions/englishlanguagerequirements/

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Benefits

The scholarship covers the full cost of UK/EU tuition fees, plus a stipend. The bursary will be limited to a maximum of £11,587 p.a. dependent upon the applicant’s financial circumstances.

There will also be additional funds available for research expenses.

Application

Please visit our website for more information.

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