Many types of bacteria are studied scientifically and used industrially to make products such as medicines, plastics and fuels, and to clean waste streams. There exists a family of bacteria called magnetotactic bacteria (MTB) that make tiny crystals of iron called magnetosomes which can be extracted and used in a wide range of biotechnological and biomedical applications thus, representing an alternative to chemically-synthesized magnetic nanoparticles (MNPs). This is advantageous as MNPs often require synthesis at high temperatures, use of organic solvents and generate hazardous waste. In contrast, magnetosomes possess unique properties: they are ferrimagnetic, biocompatible and are wrapped in an organic layer that prevents self-aggregation. However, efficient magnetosome bioprocessing is hindered by low productivities and complex biomanufacturing. The main focus of the project is to develop novel bioprocessing strategies using renewable biomass resources for enhanced production of functional magnetosomes. The project will involve: (i) Identifying what process parameters lead to MTB cease growing and hence stop magnetosome production. Physiological changes to external stimulus will be studied using flow cytometry. Nutrients consumption and product formation will be evaluated using HPLC, GC-MS and ICP-OES. Magnetosomes will be characterised using DLS and TEM. (ii) Developing alternative production strategies to achieve higher magnetosome yields. Different cultivation strategies and bioreactor configurations will be evaluated. (iii) Develop functional magnetosomes for biocatalysis applications. Functional magnetosomes will be designed using chemical coupling to functional groups or genetic engineering to express functional peptides on the magnetosome surface.
International PhD Studentships in Sustainable Biomanufacturing of Biogenic Magnetic Nanomaterials
- £4,500 fee bursary + £15,609 p.a.
- 31 January 2022
Aston University is a public research university situated in the city centre of Birmingham, England.All Scholarships from Aston University
The successful applicant should have been awarded, or expect to achieve, a Masters degree in a relevant subject with a 60% or higher weighted average, and/or a First or Upper Second Class Honours degree (or an equivalent qualification from an overseas institution) in Biochemistry or Bioprocess Engineering or Microbiology. Preferred skill requirements include knowledge/experience of Biochemistry or Bioprocess Engineering or Microbiology. Experience in biocatalysis and bioreactors would be valuable.
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This studentship includes a fee bursary to cover the Home fees rate and a maintenance allowance (subject to eligibility). The figures for 2022/23 are yet to be confirmed. For reference, in the 2021/22 academic year, the maintenance allowance was £15,609 and the Home fees were £4,500.
Overseas applicants may apply for this studentship but will need to pay the difference between the ‘Home’ and the ‘Overseas’ tuition fees. The difference between ‘Home’ and ‘Overseas’ tuition fees for 2022/23 is yet to be confirmed. For reference, in the 2021/22 academic year, the difference was £13,100.
As part of the application, you will be required to confirm that you have applied for or secured this additional funding.
For formal enquiries about the projects contact Alfred Fernandez-Castane: email@example.com
Submitting an application
As part of the application, you will need to supply:
- A copy of your current CV
- Copies of your academic qualifications for your Bachelor degree, and Masters degree; this should include both certificates and transcripts, and must be translated in to English.
- A research proposal statement*
- Two academic references
- Proof of your English Language proficiency
- A Personal Statement: Please include the supervisor name, project title, and project reference in your Personal Statement
Details of how to submit your application, and the necessary supporting documents can be found here.