Background
CBMR is a vibrant international research environment with a focus on interdisciplinary collaboration. Our researchers share a common purpose as they seek to transform the basic understanding of the mechanisms involved in metabolic health and disease, and to accelerate this knowledge toward new prevention and treatment strategies. The Center’s research has resulted in seminal discoveries as to how genes, hormones, and environmental factors influence metabolic health and disease throughout life. You can read more about us here: www.cbmr.ku.dk.
Our group and research
The candidate will be part of the Gillum Group focusing on Regulation of Metabolism and Nutrient-specific Appetite. The Gillum Group characterizes hormones and metabolites generated via the gut, gut microbiota, and liver that govern host metabolism and appetite. We identify the receptors and cellular targets through which they exert their beneficial or detrimental effects with the goal of identifying novel therapeutic possibilities.
Project Description
The ancient Greeks believed that the liver was intimately connected with both pleasure and the soul. Consistent with this old idea, we recently identified the liver as a hormonal inhibitor of sugar appetite using a combination of mouse and human genetics. Here, we seek to delineate how this anti-sugar hormone, FGF21, acts on appetitive and consummatory drives to suppress sucrose and alcohol cravings, which may lead to new cellular and molecular targets for obesity, steatohepatitis, and alcohol use disorder.
The postdoc position is a full-time position for 3 years. Starting date is 15 November 2020 or after agreement.