Clinical Research PhD Studentships at Royal Veterinary College

  • Phd
  • Home rate tuition fees + stipend
  • 31 August 2022

Project Summary:

Feline chronic kidney disease (CKD) is a heterogeneous syndrome responsible for >1 in 8 deaths of cats over 5 years of age.  Mineral bone disturbance, proteinuria and low red cell mass are associated with progressive renal injury but how these are linked to molecular mechanisms driving progression remains to be determined.  Evidence from other species suggests that exposure of tubular cells to albumin or repeated episodes of ischaemia leads to oxidative stress and induces a pro-inflammatory phenotype of tubular cells.  Also, reactive oxygen species (ROS) generated by oxidative stress trigger mitophagy, a process which removes damaged dysfunctional mitochondria and protects cells from further oxidative damage. Dysregulation of mitophagy is thought to exacerbate ROS generation and oxidative stress perpetuating the chronic inflammatory and pro-fibrotic processes.

This PhD project will examine the hypothesis that oxidative stress and dysregulated mitophagy trigger progressive feline CKD. Archived tissue, plasma and urine samples available from cats with stable and progressive CKD are available and the successful candidate will use both retrospective and prospective study design to develop experience in metabolomic and transcriptomic techniques in order to explore and address the following questions:

  1. Is oxidative stress characteristic of the progressive feline CKD metabolome?
  2. How does the renal transcriptome differ in cats with progressive versus non-progressive CKD?
  3. Can urinary transcriptomics be used to identify the pathways activated within the kidney that are associated with progression and be used to monitor response to treatment?
  4. Is there evidence to link dysregulated mitophagy to oxidative stress in progressive CKD?
Royal Veterinary College
This is a scholarship by

Royal Veterinary College

The Royal Veterinary College is the largest and longest-established vet school in the English-speaking world and is a college of the University of London.The College offers undergraduate and postgraduate programmes in veterinary medicine, veterinary nursing, and biological sciences; and CPD programmes in veterinary medicine and veterinary nursing.

All Scholarships from Royal Veterinary College

Eligibility

Essential

  • Must meet our standard PhD entry requirements
  • MRCVS or a veterinary degree registerable with MRCVS
  • Excellent communication and team working skills and a strong interest in feline medicine

Desirable

  • Prior experience of research at undergraduate or post-graduate level is desirable

Duolingo English Test

Certify your English proficiency with the Duolingo English Test! The DET is a convenient, fast, and affordable online English test accepted by over 4,000 universities around the world.

Take A Free Practice Test!

Benefits

This is a four year fully funded studentship, funded by Boehringer Ingelheim. The student will receive a stipend and "Home" rate tuition fees are covered. International applicants are welcome to apply but must be able to fund the difference between "Home" and "Overseas" tuition fees.

Apply Now

Sign Up for Scholarship Updates

Get an email every week that 10.000's of students use to get the latest scholarships.

Name
Email